Comparison of ambrisentan with sildenafil in congenital heart disease with irreversible pulmonary artery hypertension
نویسندگان
چکیده
منابع مشابه
Evaluation of QRS, QTc, and JTc intervals in Congenital Heart Disease with Pulmonary Hypertension
Background Pulmonary hypertension (PH) in congenital heart disease affects the patient’s prognosis. Prolonged QRS and QTc intervals in ECG may intensify life-threatening dysrhythmia in patients. We aimed to investigate the correlation between QRS, QTc, and JTc intervals prolongation in ECG with PH in Congenital Heart Disease (CHD) patients. Mate...
متن کاملcongenital heart disease with pulmonary hypertension; surgery or medical treatment?
pulmonary arterial hypertension (pha) is a frequent complication of congenital heart disease (chd), most commonly in systemic-to-pulmonary shunt lesions. in patients with an uncorrected left-to right shunt, pah will end up to eisenmenger’s syndrome, which is contraindication of surgery. what about patients with moderate to severe pah, who do not have criteria of eisenmenger’s syndrome; immediat...
متن کاملPharmacokinetic and Pharmacodynamic Comparison of Sildenafil‐Bosentan and Sildenafil‐Ambrisentan Combination Therapies for Pulmonary Hypertension
To elucidate whether the pharmacokinetics (PK) and pharmacodynamics (PD) of sildenafil are influenced differently when it is coadministered with bosentan (S+B) or with ambrisentan (S+A), we evaluated the PK and PD profiles of sildenafil before and after 4-5 weeks of S+A or S+B treatment in patients with pulmonary arterial hypertension. The area under the plasma concentration-time curve of silde...
متن کامل[Pulmonary hypertension associated with congenital heart disease].
INTRODUCTION Congenital heart diseases are among the most common congenital malformations at birth with an incidence of 8/1,000 live births. These defects are characterized by a heterogeneous group of abnormal defects and connections between the cardiac chambers and vessels with different haemodynamic consequences and hence, varying need for follow-up and interventions. The most common forms ar...
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ژورنال
عنوان ژورنال: Indian Heart Journal
سال: 2014
ISSN: 0019-4832
DOI: 10.1016/j.ihj.2014.10.142